ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nolc1

Full Name:

nucleolar and coiled-body phosphoprotein 1

Alias:

3230402K17Rik|AA408077|AA536818|AU046071|NOPP130|NOPP140|P130|mKIAA0035

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

19 C3

Physical Location:

46150352-46160019 on NC_000085.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9221 Symbol (Name): NOLC1 (nucleolar and coiled-body phosphoprotein 1)

Ortholog Status:

The human GeneID 9221 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1428870 (probe)
Original ID2:		Nolc1
Fold Change:		1.17
P Value:		4.00E-04
Note:		Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:3.9

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	IDA (11424213)
GO:0005730	nucleolus	Cellular Component	IDA (11470819)
GO:0015030	Cajal body	Cellular Component	IDA (11470819)
GO:0030532	small nuclear ribonucleoprotein complex	Cellular Component	TAS (11470819)
GO:0005515	protein binding	Molecular Function	IPI (11470819)
GO:0007000	nucleolus organization and biogenesis	Biological Process	IDA (11424213)