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Gene Information
Gene ID:226180
Full Name:internexin neuronal intermediate filament protein, alpha
Organism:Mus musculus (Mouse)
Genetic Location:19 C3
Physical Location:47089191-47099149 on NC_000085.5
Gene Type:protein-coding
Human Ortholog:GeneID: 9118    Symbol (Name): INA (internexin neuronal intermediate filament protein, alpha)
Ortholog Status:The human GeneID 9118 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:1448991 (probe)
Original ID2:Ina
Fold Change:1.39
P Value:4.90E-07
Note:Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:3.5
Gene Information
Original ID1:1418178 (probe)
Original ID2:Ina
Fold Change:1.33
P Value:3.20E-06
Note:Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:5.6
Dataset Information
Method:Microarray and QTL
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_146100.4NP_666212.3NC_000085.5 range: 47089191..47099149
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005882intermediate filamentCellular ComponentIEA
GO:0005883neurofilamentCellular ComponentIDA (10221457)
GO:0005198structural molecule activityMolecular FunctionIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007399nervous system developmentBiological ProcessIEA
GO:0030154cell differentiationBiological ProcessIEA
GO:0045104intermediate filament cytoskeleton organization and biogenesisBiological ProcessIMP (14561875)
GO:0060052neurofilament cytoskeleton organization and biogenesisBiological ProcessIGI (10350642)
Other Database Cross Links
NCBI Entrez Gene:226180