ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ina

Full Name:

internexin neuronal intermediate filament protein, alpha

Alias:

AV028420|MGC25352|NF-66

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

19 C3

Physical Location:

47089191-47099149 on NC_000085.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9118 Symbol (Name): INA (internexin neuronal intermediate filament protein, alpha)

Ortholog Status:

The human GeneID 9118 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1448991 (probe)
Original ID2:		Ina
Fold Change:		1.39
P Value:		4.90E-07
Note:		Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:3.5

Gene Information

Original ID1:		1418178 (probe)
Original ID2:		Ina
Fold Change:		1.33
P Value:		3.20E-06
Note:		Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:5.6

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_146100.4	NP_666212.3	NC_000085.5 range: 47089191..47099149

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005882	intermediate filament	Cellular Component	IEA
GO:0005883	neurofilament	Cellular Component	IDA (10221457)
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007399	nervous system development	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0045104	intermediate filament cytoskeleton organization and biogenesis	Biological Process	IMP (14561875)
GO:0060052	neurofilament cytoskeleton organization and biogenesis	Biological Process	IGI (10350642)