ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

KLK6

Full Name:

kallikrein-related peptidase 6

Alias:

Bssp|Klk7|MGC9355|NEUROSIN|PRSS18|PRSS9|SP59|ZYME|hK6

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

19q13.3

Physical Location:

56153698-56164740 on NC_000019.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 29245 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U62801
Fold Change:		-2.1, -2
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:		U62801
Fold Change:		3.07

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Information

Original ID1:

KLK6

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (11668196)
GO:0005576	extracellular region	Cellular Component	IDA (11668196)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12709365\|12878203)
GO:0004293	tissue kallikrein activity	Molecular Function	NAS (12878203)
GO:0004252	serine-type endopeptidase activity	Molecular Function	IEA
GO:0042982	amyloid precursor protein metabolic process	Biological Process	NAS (12709365)
GO:0042552	myelination	Biological Process	NAS (11668196)
GO:0042445	hormone metabolic process	Biological Process	NAS (11668196)
GO:0042246	tissue regeneration	Biological Process	NAS (12878203)
GO:0030574	collagen catabolic process	Biological Process	NAS (12878203)
GO:0016540	protein autoprocessing	Biological Process	NAS (12878203)
GO:0009611	response to wounding	Biological Process	NAS (12016211)
GO:0007417	central nervous system development	Biological Process	NAS (12589961)
GO:0006508	proteolysis	Biological Process	IEA
GO:0045595	regulation of cell differentiation	Biological Process	NAS (11668196)