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Gene Information
Gene ID:29245
Symbol:Klk6
Full Name:kallikrein related-peptidase 6
Alias:Prss9
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q22
Physical Location:94254349-94261499 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5653    Symbol (Name): KLK6 (kallikrein-related peptidase 6)
Ortholog Status:The human GeneID 5653 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Klk6
Fold Change:1.2
P Value:0.004
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019175.1NP_062048.1NC_005100.2 range: 94254349..94261499
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0004252serine-type endopeptidase activityMolecular FunctionIEA
GO:0004293tissue kallikrein activityMolecular FunctionTAS (9334391)
GO:0005515protein bindingMolecular FunctionISS
GO:0008233peptidase activityMolecular FunctionIEA
GO:0006508proteolysisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:29245
RGD:3419
Ensembl:ENSRNOG00000018742
dbSNP:Klk6