ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HSPA1B

Full Name:

heat shock 70kDa protein 1B

Alias:

HSP70-1B|HSP70-2|HSPA1A

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p21.3

Physical Location:

31903502-31906009 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 15511 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M59830
Fold Change:		6.17

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005346.4	NP_005337.2	NC_000006.10 range: 31903502..31906009

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	TAS (16130169)
GO:0005634	nucleus	Cellular Component	TAS (10205060)
GO:0005737	cytoplasm	Cellular Component	TAS (16130169)
GO:0005739	mitochondrion	Cellular Component	TAS (16130169)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0051082	unfolded protein binding	Molecular Function	TAS (16130169)
GO:0006402	mRNA catabolic process	Biological Process	TAS (10205060)
GO:0006916	anti-apoptosis	Biological Process	TAS (16130169)
GO:0006986	response to unfolded protein	Biological Process	TAS (10859165)