ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hspa1b

Full Name:

heat shock protein 1B

Alias:

Hsp70|Hsp70-1|Hsp70.1|hsp68

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 B1|17 18.9 cM

Physical Location:

35093373-35096182 on NC_000083.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3304 Symbol (Name): HSPA1B (heat shock 70kDa protein 1B)

Ortholog Status:

The human GeneID 3304 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hsp70
Fold Change:		1.72
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010478.2	NP_034608.2	NC_000083.5 range: 35093373..35096182, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11116152\|11527400)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0000723	telomere maintenance	Biological Process	IMP (14701760)
GO:0006281	DNA repair	Biological Process	IMP (14701760)
GO:0006916	anti-apoptosis	Biological Process	IDA (11879190)
GO:0006950	response to stress	Biological Process	IEA
GO:0009408	response to heat	Biological Process	IMP (14701760)
GO:0043154	negative regulation of caspase activity	Biological Process	IDA (11879190)