ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HLA-DRA

Full Name:

major histocompatibility complex, class II, DR alpha

Alias:

HLA-DRA1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p21.3

Physical Location:

32515624-32520800 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X00274
Fold Change:		-1.7, -1.6
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:		J00194
Fold Change:		-2.41

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019111.3	NP_061984.2	NC_000006.10 range: 32515624..32520800

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042613	MHC class II protein complex	Cellular Component	IEA
GO:0005764	lysosome	Cellular Component	IDA (8890155)
GO:0005886	plasma membrane	Cellular Component	EXP (11048639\|11827988\|15489916\|17652306)
GO:0005886	plasma membrane	Cellular Component	IDA (8890155)
GO:0005887	integral to plasma membrane	Cellular Component	NAS (6304715\|6812963)
GO:0016020	membrane	Cellular Component	IEA
GO:0032395	MHC class II receptor activity	Molecular Function	NAS (6304715\|6812963)
GO:0019882	antigen processing and presentation	Biological Process	IEA
GO:0006955	immune response	Biological Process	NAS (6304715\|6812963)
GO:0006955	immune response	Biological Process	IEA
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	Biological Process	IEA