| Gene Information |
| Gene ID: | | 7644 |
| Symbol: | | ZNF91 |
| Full Name: | | zinc finger protein 91 |
| Alias: | | HPF7|HTF10 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 19 |
| Genetic Location: | | 19p13.1-p12 |
| Physical Location: | | 23332337-23370108 on NC_000019.8, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | L11672 | | Fold Change: | | 2.13 | | P Value: | | 0.0093 |
| | Dataset Information | | Name: | | 12774316 | | Method: | | Microarray | | Tissue: | | Temporal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed | | Summary: | | To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly. |
| | Gene Information | | Original ID1: | | L11672 | | Fold Change: | | -2.09 |
| | Dataset Information | | Name: | | 15236863 | | Method: | | Microarray | | Tissue: | | Prefrontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed | | Summary: | | We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005622 | intracellular | Cellular Component | IEA | |
| GO:0005634 | nucleus | Cellular Component | NAS | |
| GO:0003700 | transcription factor activity | Molecular Function | NAS (2023909) | |
| GO:0008270 | zinc ion binding | Molecular Function | NAS (8467795) | |
| GO:0046872 | metal ion binding | Molecular Function | IEA | |
| GO:0006350 | transcription | Biological Process | IEA | |
| GO:0006355 | regulation of transcription, DNA-dependent | Biological Process | NAS | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 7644 |
| HGNC: | | 13166 |
| Ensembl: | | ENSG00000167232 |
| MIM: | | 603971 |
| HPRD: | | 04916 |
| HuGE Navigator: | | 7644 |
| dbSNP: | | ZNF91 |
| GeneCard: | | ZNF91 |
| AceView: | | ZNF91 |
