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Dataset Description
  • Dataset Name: 12774316
  • Species: Human
  • Method: Microarray
  • No. of Genes: 167
  • Tissue: Temporal cortex
  • Phenotype: Alcohol dependence (AD)/Alcohol abuse/Alcoholism
  • Publication: Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
  • Dataset Summary: To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

    Gene list of this dataset (167 genes)
    Page: 1 2 3 4 list all   
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    4200ME2malic enzyme 2, NAD(+)-dependent, mitochondrial6p25-p24|18q21M55905 
    4976OPA1optic atrophy 1 (autosomal dominant)3q28-q29|3q28-q29AB011139 
    4709NDUFB3NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa2q31.3AA203354 
    3336HSPE1heat shock 10kDa protein 1 (chaperonin 10)2q33.1AI912041 
    1329COX5Bcytochrome c oxidase subunit Vb2cen-q13M19961 
    10456HAX1HCLS1 associated protein X-11q21.3U68566 
    9868TOMM70Atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)3q12.2AB018262 
    36ACADSBacyl-Coenzyme A dehydrogenase, short/branched chain10q26.13U12778 
    10632ATP5LATP synthase, H+ transporting, mitochondrial F0 complex, subunit G11q23.3AA917672 
    617BCS1LBCS1-like (yeast)2q33AF038195 
    27089UQCRQubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa5q31.1AI540957 
    1339COX6A2cytochrome c oxidase subunit VIa polypeptide 216pF27891 
    25820ARIH1ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)15q24AJ009771 
    997CDC34cell division cycle 34 homolog (S. cerevisiae)19p13.3L22005 
    7337UBE3Aubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)15q11-q13U84404 
    5715PSMD9proteasome (prosome, macropain) 26S subunit, non-ATPase, 912q24.31-q24.32AB003177 
    6477SIAH1seven in absentia homolog 1 (Drosophila)16q12U76247 
    10277UBE4Bubiquitination factor E4B (UFD2 homolog, yeast)1p36.3AB014584 
    7375USP4ubiquitin specific peptidase 4 (proto-oncogene)3p21.3U20657 
    823CAPN1calpain 1, (mu/I) large subunit11q13X04366 
    1842ECM2extracellular matrix protein 2, female organ and adipocyte specific9q22.3AB011792 
    9620CELSR1cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)22q13.3AL031588 
    1010CDH12cadherin 12, type 2 (N-cadherin 2)5p14-p13L34057 
    9752PCDHA9protocadherin alpha 95q31AB002343 
    3681ITGADintegrin, alpha D16p11.2U40279 
    324APCadenomatous polyposis coli5q21-q22M74088 
    7010TEKTEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)9p21L06139 
    10267RAMP1receptor (G protein-coupled) activity modifying protein 12q36-q37.1AJ001014 
    6450SH3BGRSH3 domain binding glutamic acid-rich protein21q22.3X93498 
    5532PPP3CBprotein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform10q21-q22M29550 
    5533PPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform8p21.3S46622 
    22876INPP5Finositol polyphosphate-5-phosphatase F10q26.11AB023183 
    1452CSNK1A1casein kinase 1, alpha 15q32L37042 
    7016TESK1testis-specific kinase 19p13D50863 
    6009RHEBRas homolog enriched in brain7q36D78132 
    83941TM2D1TM2 domain containing 11p31.3AI057115 
    9770RASSF2Ras association (RalGDS/AF-6) domain family member 220pter-p12.1D79990 
    3643INSRinsulin receptor19p13.3-p13.2X02160 
    11236RNF139ring finger protein 1398q24AF064801 
    55816DOK5docking protein 520q13.2AL050069 
    7220TRPC1transient receptor potential cation channel, subfamily C, member 13q22-q24X89066 
    7881KCNAB1potassium voltage-gated channel, shaker-related subfamily, beta member 13q26.1L39833 
    23673STX12syntaxin 121p35-p34.1AL035306 
    8943AP3D1adaptor-related protein complex 3, delta 1 subunit19p13.3AF002163 
    3791KDRkinase insert domain receptor (a type III receptor tyrosine kinase)4q11-q12AF035121 
    5336PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific)16q24.1M37238 
    2822GPLD1glycosylphosphatidylinositol specific phospholipase D16p22.3-p22.2L11702 
    5791PTPREprotein tyrosine phosphatase, receptor type, E10q26X54134 
    9088PKMYT1protein kinase, membrane associated tyrosine/threonine 116p13.3AF014118 
    Page: 1 2 3 4 list all