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Gene Information
Gene ID:997
Full Name:cell division cycle 34 homolog (S. cerevisiae)
Organism:Homo sapiens (Human)
Genetic Location:19p13.3
Physical Location:482732-493086 on NC_000019.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L22005
Fold Change:0.66
P Value:0.0027
Dataset Information
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004359.1NP_004350.1NC_000019.8 range: 482732..493086
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentNAS (8248134)
GO:0004842ubiquitin-protein ligase activityMolecular FunctionNAS (8248134)
GO:0005515protein bindingMolecular FunctionIPI (17274640)
GO:0016874ligase activityMolecular FunctionIEA
GO:0000082G1/S transition of mitotic cell cycleBiological ProcessNAS (8248134)
GO:0006270DNA replication initiationBiological ProcessNAS (8248134)
GO:0006512ubiquitin cycleBiological ProcessNAS (8248134)
GO:0051246regulation of protein metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:997
HuGE Navigator:997