ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PSMD9

Full Name:

proteasome (prosome, macropain) 26S subunit, non-ATPase, 9

Alias:

MGC8644|Rpn4|p27

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12q24.31-q24.32

Physical Location:

120811028-120840153 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002813.4	NP_002804.2	NC_000012.10 range: 120811028..120840153

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS (10567574)
GO:0005829	cytosol	Cellular Component	IEA
GO:0005838	proteasome regulatory particle	Cellular Component	NAS (9653651)
GO:0003713	transcription coactivator activity	Molecular Function	ISS (10567574)
GO:0005515	protein binding	Molecular Function	IEA
GO:0043425	bHLH transcription factor binding	Molecular Function	ISS (10567574)
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (15029244)
GO:0046676	negative regulation of insulin secretion	Biological Process	ISS (16099819)
GO:0045941	positive regulation of transcription	Biological Process	ISS (10567574\|16293776)
GO:0032024	positive regulation of insulin secretion	Biological Process	ISS (10567574)
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	EXP (11285280)
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	NAS (9653651)
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (12791267)