ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SIAH1

Full Name:

seven in absentia homolog 1 (Drosophila)

Alias:

HUMSIAH|Siah-1|Siah-1a|hSIAH1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

16q12

Physical Location:

46951942-46976729 on NC_000016.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 20437 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	TAS (9334332)
GO:0016874	ligase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IDA (11863358)
GO:0008022	protein C-terminus binding	Molecular Function	IPI (11389840)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0030163	protein catabolic process	Biological Process	IDA (11389840)
GO:0030154	cell differentiation	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	TAS (9334332)
GO:0009653	anatomical structure morphogenesis	Biological Process	TAS (9403064)
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0007411	axon guidance	Biological Process	TAS (9334332)
GO:0006915	apoptosis	Biological Process	TAS (9403064)
GO:0007283	spermatogenesis	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007399	nervous system development	Biological Process	TAS (9334332)