ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RAMP1

Full Name:

receptor (G protein-coupled) activity modifying protein 1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q36-q37.1

Physical Location:

238432925-238485494 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 51801 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S2973

2.20

0.0007

235696080

D2S140

1.95

0.0014

241388318

Region:		235696080-241388318
Phenotype:		WDSFS (withdrawal symptoms factor score)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005855.2	NP_005846.1	NC_000002.10 range: 238432925..238485494

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	TAS (9620797)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (9620797)
GO:0008565	protein transporter activity	Molecular Function	TAS (9620797)
GO:0008565	protein transporter activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	Biological Process	TAS (9620797)
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	Biological Process	IEA