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Dataset Description
  • Dataset Name: 12774316
  • Species: Human
  • Method: Microarray
  • No. of Genes: 167
  • Tissue: Temporal cortex
  • Phenotype: Alcohol dependence (AD)/Alcohol abuse/Alcoholism
  • Publication: Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
  • Dataset Summary: To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

    Gene list of this dataset (167 genes)
    Page: 1 2 3 4 list all   
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    6414SEPP1selenoprotein P, plasma, 15q31Z11793 
    821CANXcalnexin5q35L10284 
    3920LAMP2lysosomal-associated membrane protein 2Xq24U36336 
    6902TBCAtubulin folding cofactor A5q14.1AF038952 
    4430MYO1Bmyosin IB2q12-q34AJ001381 
    9276COPB2coatomer protein complex, subunit beta 2 (beta prime)3q23X70476 
    1605DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)3p21L19711 
    5346PLINperilipin15q26AB005293 
    10947AP3M2adaptor-related protein complex 3, mu 2 subunit8p11.2D38293 
    4515MTCP1mature T-cell proliferation 1Xq28Z24459 
    11145HRASLS3HRAS-like suppressor 311q12.3-q13.1X92814 
    23169SLC35D1solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D11p32-p31D87449 
    11235PDCD10programmed cell death 103q26.1AF022385 
        L049851 
    10105PPIFpeptidylprolyl isomerase F (cyclophilin F)10q22-q23M80254 
    221823PRPS1L1phosphoribosyl pyrophosphate synthetase 1-like 17p21.1M57423 
    1549CYP2A7cytochrome P450, family 2, subfamily A, polypeptide 719q13.2M33317 
    10965ACOT2acyl-CoA thioesterase 214q24.3L40401 
    4647MYO7Amyosin VIIA11q13.5U39226 
    1822ATN1atrophin 112p13.31D31840 
    9121SLC16A5solute carrier family 16, member 5 (monocarboxylic acid transporter 6)17q25.1U59299 
    9311ACCN3amiloride-sensitive cation channel 37q35AB010575 
    23443SLC35A3solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A31p21AB021981 
    2760GM2AGM2 ganglioside activator5q31.3-q33.1AA224768 
    118ADD1adducin 1 (alpha)4p16.3L07261 
    3107HLA-Cmajor histocompatibility complex, class I, C6p21.3X96754 
    4583MUC2mucin 2, oligomeric mucus/gel-forming11p15.5M57417 
    10616RBCK1RanBP-type and C3HC4-type zinc finger containing 120p13AA160708 
    65110UPF3AUPF3 regulator of nonsense transcripts homolog A (yeast)13q34N36842 
    57498KIDINS220-2p24W27233 
    55786ZNF415zinc finger protein 41519q13.41AF038179 
        AF052141 
    51029FAM152Afamily with sequence similarity 152, member A1q44AL049397 
    129642MBOAT2membrane bound O-acyltransferase domain containing 22p25.1AF052107 
    23136EPB41L3erythrocyte membrane protein band 4.1-like 318p11.32AB023204 
    9716AQRaquarius homolog (mouse)15q14AB011132 
    9890LPPR4-1p21.2AB007924 
    9706ULK2unc-51-like kinase 2 (C. elegans)17p11.2AB014523 
    92482LOC92482-10q25.2AI692348 
    84869CBR4carbonyl reductase 44q32.3AL049442 
    9816KIAA0133KIAA01331q42.13D50923 
        AW026535 
    23394ADNPactivity-dependent neuroprotector homeobox20q13.13AB018327 
    22828RBM16RNA binding motif protein 166q25.1-q25.3AB029039 
    23244PDS5APDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)4p14AB014548 
    10907TXNL4Athioredoxin-like 4A18q23AF023612 
    10447FAM3Cfamily with sequence similarity 3, member C7q31D87120 
    9802DAZAP2DAZ associated protein 212q12D31767 
    57158JPH2junctophilin 220q13.12AL035447 
    10972TMED10transmembrane emp24-like trafficking protein 10 (yeast)14q24.3L40397 
    Page: 1 2 3 4 list all