ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

EPB41L3

Full Name:

erythrocyte membrane protein band 4.1-like 3

Alias:

4.1B|DAL-1|DAL1|FLJ37633|KIAA0987

Organism:

Homo sapiens (Human)

Chromosome:

18

Genetic Location:

18p11.32

Physical Location:

5382387-5533985 on NC_000018.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AB023204
Fold Change:		0.84
P Value:		0.0067

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012307.2	NP_036439.2	NC_000018.8 range: 5382387..5533985, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	NAS (9892180)
GO:0019898	extrinsic to membrane	Cellular Component	IEA
GO:0005911	intercellular junction	Cellular Component	IDA (12234973)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0003779	actin binding	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0008150	biological_process	Biological Process	ND
GO:0030866	cortical actin cytoskeleton organization and biogenesis	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000082397

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: