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Gene Information
Gene ID:65110
Symbol:UPF3A
Full Name:UPF3 regulator of nonsense transcripts homolog A (yeast)
Alias:HUPF3A|RENT3A|UPF3
Organism:Homo sapiens (Human)
Chromosome:13
Genetic Location:13q34
Physical Location:114065179-114089384 on NC_000013.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:N36842
Fold Change:0.8
P Value:0.0024
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_023011.2NP_075387.1NC_000013.9 range: 114065179..114089384
NM_080687.1NP_542418.1NC_000013.9 range: 114065179..114089384
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentNAS (11163187)
GO:0005737cytoplasmCellular ComponentNAS (11163187)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0003723RNA bindingMolecular FunctionIEA
GO:0005487nucleocytoplasmic transporter activityMolecular FunctionNAS (11163187)
GO:0005515protein bindingMolecular FunctionIPI (15231747)
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayBiological ProcessNAS (11163187)
GO:0006810transportBiological ProcessIEA
GO:0051028mRNA transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:65110
HGNC:20332
Ensembl:ENSG00000169062
MIM:605530
HPRD:09274
HuGE Navigator:65110
dbSNP:UPF3A
GeneCard:UPF3A
AceView:UPF3A