Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:10907
Symbol:TXNL4A
Full Name:thioredoxin-like 4A
Alias:DIB1|DIM1|HsT161|TXNL4|U5-15kD
Organism:Homo sapiens (Human)
Chromosome:18
Genetic Location:18q23
Physical Location:75833854-75849519 on NC_000018.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF023612
Fold Change:0.8
P Value:0.014
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006701.2NP_006692.1NC_000018.8 range: 75833854..75849519, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005681spliceosomeCellular ComponentIEA
GO:0005681spliceosomeCellular ComponentTAS (10610776)
GO:0031202RNA splicing factor activity, transesterification mechanismMolecular FunctionTAS (10610776)
GO:0000245spliceosome assemblyBiological ProcessTAS (10610776)
GO:0008380RNA splicingBiological ProcessIEA
GO:0007067mitosisBiological ProcessNAS
GO:0007067mitosisBiological ProcessIEA
GO:0007049cell cycleBiological ProcessIEA
GO:0051301cell divisionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:10907
HGNC:30551
Ensembl:ENSG00000141759
MIM:611595
HPRD:18252
HuGE Navigator:10907
dbSNP:TXNL4A
GeneCard:TXNL4A
AceView:TXNL4A