ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

COPB2

Full Name:

coatomer protein complex, subunit beta 2 (beta prime)

Alias:

beta'-COP

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3q23

Physical Location:

140559122-140591150 on NC_000003.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 45757 Rat: 60384 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004766.2	NP_004757.1	NC_000003.10 range: 140559122..140591150, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0030117	membrane coat	Cellular Component	IEA
GO:0030126	COPI vesicle coat	Cellular Component	IDA (8335000)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (8533093\|8599108)
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (17220478\|17353931)
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0016192	vesicle-mediated transport	Biological Process	IEA
GO:0016044	membrane organization and biogenesis	Biological Process	EXP (11031247)
GO:0006891	intra-Golgi vesicle-mediated transport	Biological Process	IDA (8335000)
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	Biological Process	TAS (11030615)
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	Biological Process	EXP (11031247)
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0048205	COPI coating of Golgi vesicle	Biological Process	EXP (16956762)