ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Copb2

Full Name:

coatomer protein complex, subunit beta 2 (beta prime)

Alias:

MGC93460

Organism:

Rattus norvegicus (Rat)

Chromosome:

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9276 Symbol (Name): COPB2 (coatomer protein complex, subunit beta 2 (beta prime))

Ortholog Status:

The human GeneID 9276 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.37178
Original ID2:		Copb2
Fold Change:		1.19
P Value:		0.00954
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IDA (9360998)
GO:0030117	membrane coat	Cellular Component	IEA
GO:0030126	COPI vesicle coat	Cellular Component	ISS
GO:0005794	Golgi apparatus	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IDA (9360998)
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0005080	protein kinase C binding	Molecular Function	IDA (9360998)
GO:0008565	protein transporter activity	Molecular Function	IEA
GO:0006891	intra-Golgi vesicle-mediated transport	Biological Process	ISS
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0006461	protein complex assembly	Biological Process	IEA
GO:0048193	Golgi vesicle transport	Biological Process	IPI (9360998)