ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

beta'Cop

Alias:

CG6699|beta'-COP|dbeta'COP

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

34B9-34B9

Physical Location:

13378896-13382390 on NT_033779.4

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9276 Symbol (Name): COPB2 (coatomer protein complex, subunit beta 2 (beta prime))

Ortholog Status:

The human GeneID 9276 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		beta'Cop
P Value:		6.99E-03
Note:		Acute down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_080097.2	NP_524836.2	NT_033779.4 range: 13378896..13382390

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030126	COPI vesicle coat	Cellular Component	NAS
GO:0030117	membrane coat	Cellular Component	IEA
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0008565	protein transporter activity	Molecular Function	IEA
GO:0016192	vesicle-mediated transport	Biological Process	IEA
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	Biological Process	NAS
GO:0006888	ER to Golgi vesicle-mediated transport	Biological Process	NAS
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0006461	protein complex assembly	Biological Process	IEA
GO:0048194	Golgi vesicle budding	Biological Process	NAS