ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TMED10

Full Name:

transmembrane emp24-like trafficking protein 10 (yeast)

Alias:

P24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q24.3

Physical Location:

74667923-74713101 on NC_000014.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AW504797

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006827.5	NP_006818.3	NC_000014.7 range: 74667923..74713101, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0042589	zymogen granule membrane	Cellular Component	ISS
GO:0042470	melanosome	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	ISS
GO:0016020	membrane	Cellular Component	IEA
GO:0005801	cis-Golgi network	Cellular Component	ISS
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005793	ER-Golgi intermediate compartment	Cellular Component	IDA (15308636)
GO:0005792	microsome	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	IPI (16641999)
GO:0015031	protein transport	Biological Process	IEA
GO:0016192	vesicle-mediated transport	Biological Process	IEA
GO:0045055	regulated secretory pathway	Biological Process	ISS
GO:0048199	vesicle targeting, to, from or within Golgi	Biological Process	ISS