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Gene Information
Gene ID:221823
Symbol:PRPS1L1
Full Name:phosphoribosyl pyrophosphate synthetase 1-like 1
Alias:PRPS1|PRPS3|PRPSL|PRS-III
Organism:Homo sapiens (Human)
Chromosome:7
Genetic Location:7p21.1
Physical Location:18032921-18034010 on NC_000007.12, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M57423
Fold Change:1.48
P Value:0.0023
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_175886.2NP_787082.1NC_000007.12 range: 18032921..18034010, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0004749ribose phosphate diphosphokinase activityMolecular FunctionNAS (2168892)
GO:0016301kinase activityMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0009116nucleoside metabolic processBiological ProcessIEA
GO:0009156ribonucleoside monophosphate biosynthetic processBiological ProcessNAS
GO:0009165nucleotide biosynthetic processBiological ProcessIEA
GO:0044249cellular biosynthetic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:221823
HGNC:9463
Ensembl:ENSG00000153287
MIM:611566
HPRD:17914
HuGE Navigator:221823
dbSNP:PRPS1L1
GeneCard:PRPS1L1
AceView:PRPS1L1