ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PRPS1L1

Full Name:

phosphoribosyl pyrophosphate synthetase 1-like 1

Alias:

PRPS1|PRPS3|PRPSL|PRS-III

Organism:

Homo sapiens (Human)

Chromosome:

7

Genetic Location:

7p21.1

Physical Location:

18032921-18034010 on NC_000007.12, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M57423
Fold Change:		1.48
P Value:		0.0023

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_175886.2	NP_787082.1	NC_000007.12 range: 18032921..18034010, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004749	ribose phosphate diphosphokinase activity	Molecular Function	NAS (2168892)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0009116	nucleoside metabolic process	Biological Process	IEA
GO:0009156	ribonucleoside monophosphate biosynthetic process	Biological Process	NAS
GO:0009165	nucleotide biosynthetic process	Biological Process	IEA
GO:0044249	cellular biosynthetic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000153287

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: