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Gene Information
Gene ID:821
Full Name:calnexin
Organism:Homo sapiens (Human)
Genetic Location:5q35
Physical Location:179058535-179091247 on NC_000005.8
Gene Type:protein-coding
Orthologs:This gene has Mouse: 12330 Rat: 29144 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L10284
Fold Change:0.83
P Value:0.0031
Dataset Information
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001024649.1NP_001019820.1NC_000005.8 range: 179058535..179091247
NM_001746.3NP_001737.1NC_000005.8 range: 179058535..179091247
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0042470melanosomeCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIDA (15467828)
GO:0005783endoplasmic reticulumCellular ComponentIDA (14966132|15467828)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0051082unfolded protein bindingMolecular FunctionIEA
GO:0051082unfolded protein bindingMolecular FunctionNAS
GO:0005529sugar bindingMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionTAS (8136357)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0006457protein foldingBiological ProcessIEA
GO:0009306protein secretionBiological ProcessTAS (8055875)
GO:0001525angiogenesisBiological ProcessIDA (15467828)
Other Database Cross Links
NCBI Entrez Gene:821
HuGE Navigator:821