ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Canx

Full Name:

calnexin

Organism:

Rattus norvegicus (Rat)

Chromosome:

10

Genetic Location:

10q22

Physical Location:

35854050-35869403 on NC_005109.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 821 Symbol (Name): CANX (calnexin)

Ortholog Status:

The human GeneID 821 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L18889
Fold Change:		3.4
Tissue:		Medial prefrontal (cingulate) cortex

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_172008.2	NP_742005.1	NC_005109.2 range: 35854050..35869403, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	ISS
GO:0042470	melanosome	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	ISS
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0051082	unfolded protein binding	Molecular Function	IEA
GO:0005529	sugar binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI (17170088)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0006457	protein folding	Biological Process	IEA
GO:0001525	angiogenesis	Biological Process	ISS

Other Database Cross Links

NCBI Entrez Gene:

RGD:

Ensembl:

ENSRNOG00000003343

dbSNP: