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Gene Information
Gene ID:29144
Full Name:calnexin
Organism:Rattus norvegicus (Rat)
Genetic Location:10q22
Physical Location:35854050-35869403 on NC_005109.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 821    Symbol (Name): CANX (calnexin)
Ortholog Status:The human GeneID 821 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L18889
Fold Change:3.4
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_172008.2NP_742005.1NC_005109.2 range: 35854050..35869403, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005783endoplasmic reticulumCellular ComponentISS
GO:0042470melanosomeCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISS
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0051082unfolded protein bindingMolecular FunctionIEA
GO:0005529sugar bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (17170088)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0006457protein foldingBiological ProcessIEA
GO:0001525angiogenesisBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:29144