ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC35A3

Full Name:

solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3

Alias:

DKFZp781P1297

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p21

Physical Location:

100208127-100261593 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012243.1	NP_036375.1	NC_000001.9 range: 100208127..100261593

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	TAS (10393322)
GO:0005462	UDP-N-acetylglucosamine transmembrane transporter activity	Molecular Function	TAS (10393322)
GO:0005351	sugar:hydrogen symporter activity	Molecular Function	IEA
GO:0005338	nucleotide-sugar transmembrane transporter activity	Molecular Function	IEA
GO:0015780	nucleotide-sugar transport	Biological Process	IEA
GO:0015788	UDP-N-acetylglucosamine transport	Biological Process	TAS (10393322)
GO:0006047	UDP-N-acetylglucosamine metabolic process	Biological Process	TAS (10393322)