ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MUC2

Full Name:

mucin 2, oligomeric mucus/gel-forming

Alias:

MLP|SMUC

Organism:

Homo sapiens (Human)

Chromosome:

11

Genetic Location:

11p15.5

Physical Location:

1064901-1094418 on NC_000011.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M57417
Fold Change:		2.81
P Value:		0.0081

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Information

Original ID1:

MUC2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002457.2	NP_002448.2	NC_000011.8 range: 1064901..1094418

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	NAS (2703501)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	ISS (2254452)
GO:0005615	extracellular space	Cellular Component	NR
GO:0005201	extracellular matrix structural constituent	Molecular Function	NAS (2703501)
GO:0030197	extracellular matrix constituent, lubricant activity	Molecular Function	ISS (2254452)
GO:0008150	biological_process	Biological Process	ND
GO:0030277	maintenance of gastrointestinal epithelium	Biological Process	ISS (2254452)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: