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Gene Information
Gene ID:4647
Symbol:MYO7A
Full Name:myosin VIIA
Alias:DFNA11|DFNB2|MYOVIIA|MYU7A|NSRD2|USH1B
Organism:Homo sapiens (Human)
Chromosome:11
Genetic Location:11q13.5
Physical Location:76516963-76603931 on NC_000011.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U39226
Fold Change:1.57
P Value:0.023
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000260.3NP_000251.3NC_000011.8 range: 76516963..76603931
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentIDA (15300860)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005856cytoskeletonCellular ComponentIEA
GO:0016459myosin complexCellular ComponentIEA
GO:0045202synapseCellular ComponentIDA (8842737)
GO:0001917photoreceptor inner segmentCellular ComponentIDA (8842737)
GO:0001750photoreceptor outer segmentCellular ComponentIDA (8842737)
GO:0005765lysosomal membraneCellular ComponentIDA (16001398)
GO:0000146microfilament motor activityMolecular FunctionNAS (12466270)
GO:0046983protein dimerization activityMolecular FunctionRCA (8622919)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0003779actin bindingMolecular FunctionIEA
GO:0005488bindingMolecular FunctionIEA
GO:0005516calmodulin bindingMolecular FunctionIMP (15300860)
GO:0007605sensory perception of soundBiological ProcessIMP (7870171)
GO:0007601visual perceptionBiological ProcessIMP (7870171)
GO:0030048actin filament-based movementBiological ProcessNAS (12466270)
GO:0007040lysosome organization and biogenesisBiological ProcessIDA (16001398)
GO:0050896response to stimulusBiological ProcessIEA
GO:0050957equilibrioceptionBiological ProcessIMP (7870171)
Other Database Cross Links
NCBI Entrez Gene:4647
HGNC:7606
Ensembl:
MIM:276903
HPRD:02043
HuGE Navigator:4647
dbSNP:MYO7A
GeneCard:MYO7A
AceView:MYO7A