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Dataset Description
  • Dataset Name: 12774316
  • Species: Human
  • Method: Microarray
  • No. of Genes: 167
  • Tissue: Temporal cortex
  • Phenotype: Alcohol dependence (AD)/Alcohol abuse/Alcoholism
  • Publication: Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
  • Dataset Summary: To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

    Gene list of this dataset (167 genes)
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    4200ME2malic enzyme 2, NAD(+)-dependent, mitochondrial6p25-p24|18q21M55905 
    4976OPA1optic atrophy 1 (autosomal dominant)3q28-q29|3q28-q29AB011139 
    4709NDUFB3NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa2q31.3AA203354 
    3336HSPE1heat shock 10kDa protein 1 (chaperonin 10)2q33.1AI912041 
    1329COX5Bcytochrome c oxidase subunit Vb2cen-q13M19961 
    10456HAX1HCLS1 associated protein X-11q21.3U68566 
    9868TOMM70Atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)3q12.2AB018262 
    36ACADSBacyl-Coenzyme A dehydrogenase, short/branched chain10q26.13U12778 
    10632ATP5LATP synthase, H+ transporting, mitochondrial F0 complex, subunit G11q23.3AA917672 
    617BCS1LBCS1-like (yeast)2q33AF038195 
    27089UQCRQubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa5q31.1AI540957 
    1339COX6A2cytochrome c oxidase subunit VIa polypeptide 216pF27891 
    25820ARIH1ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)15q24AJ009771 
    997CDC34cell division cycle 34 homolog (S. cerevisiae)19p13.3L22005 
    7337UBE3Aubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)15q11-q13U84404 
    5715PSMD9proteasome (prosome, macropain) 26S subunit, non-ATPase, 912q24.31-q24.32AB003177 
    6477SIAH1seven in absentia homolog 1 (Drosophila)16q12U76247 
    10277UBE4Bubiquitination factor E4B (UFD2 homolog, yeast)1p36.3AB014584 
    7375USP4ubiquitin specific peptidase 4 (proto-oncogene)3p21.3U20657 
    823CAPN1calpain 1, (mu/I) large subunit11q13X04366 
    1842ECM2extracellular matrix protein 2, female organ and adipocyte specific9q22.3AB011792 
    9620CELSR1cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)22q13.3AL031588 
    1010CDH12cadherin 12, type 2 (N-cadherin 2)5p14-p13L34057 
    9752PCDHA9protocadherin alpha 95q31AB002343 
    3681ITGADintegrin, alpha D16p11.2U40279 
    324APCadenomatous polyposis coli5q21-q22M74088 
    7010TEKTEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)9p21L06139 
    10267RAMP1receptor (G protein-coupled) activity modifying protein 12q36-q37.1AJ001014 
    6450SH3BGRSH3 domain binding glutamic acid-rich protein21q22.3X93498 
    5532PPP3CBprotein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform10q21-q22M29550 
    5533PPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform8p21.3S46622 
    22876INPP5Finositol polyphosphate-5-phosphatase F10q26.11AB023183 
    1452CSNK1A1casein kinase 1, alpha 15q32L37042 
    7016TESK1testis-specific kinase 19p13D50863 
        A1365215 
    6009RHEBRas homolog enriched in brain7q36D78132 
    83941TM2D1TM2 domain containing 11p31.3AI057115 
    9770RASSF2Ras association (RalGDS/AF-6) domain family member 220pter-p12.1D79990 
    3643INSRinsulin receptor19p13.3-p13.2X02160 
    11236RNF139ring finger protein 1398q24AF064801 
    55816DOK5docking protein 520q13.2AL050069 
    7220TRPC1transient receptor potential cation channel, subfamily C, member 13q22-q24X89066 
    7881KCNAB1potassium voltage-gated channel, shaker-related subfamily, beta member 13q26.1L39833 
    23673STX12syntaxin 121p35-p34.1AL035306 
    8943AP3D1adaptor-related protein complex 3, delta 1 subunit19p13.3AF002163 
    3791KDRkinase insert domain receptor (a type III receptor tyrosine kinase)4q11-q12AF035121 
    5336PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific)16q24.1M37238 
    2822GPLD1glycosylphosphatidylinositol specific phospholipase D16p22.3-p22.2L11702 
    5791PTPREprotein tyrosine phosphatase, receptor type, E10q26X54134 
    9088PKMYT1protein kinase, membrane associated tyrosine/threonine 116p13.3AF014118 
    8851CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)17q11.2X80343 
    6792CDKL5cyclin-dependent kinase-like 5Xp22X89059 
    2323FLT3LGfms-related tyrosine kinase 3 ligand19q13.3U03858 
    23616SH3BP1SH3-domain binding protein 122q13.1Z83844 
    2212FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)1q23M31932 
    2099ESR1estrogen receptor 16q25.1X03635 
    958CD40CD40 molecule, TNF receptor superfamily member 520q12-q13.2X60592 
    10692RRHretinal pigment epithelium-derived rhodopsin homolog4q25AF012270 
    3068HDGFhepatoma-derived growth factor (high-mobility group protein 1-like)1q21-q23D16431 
    6944VPS72vacuolar protein sorting 72 homolog (S. cerevisiae)1q21D43642 
    5936RBM4RNA binding motif protein 411q13U89505 
    546ATRXalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)Xq13.1-q21.1U72936 
    546ATRXalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)Xq13.1-q21.1U72936 
    1660DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 91q25L13848 
    1665DHX15DEAH (Asp-Glu-Ala-His) box polypeptide 154p15.3AB001636 
    1466CSRP2cysteine and glycine-rich protein 212q21.1U57646 
    1465CSRP1cysteine and glycine-rich protein 11q32M33146 
    86ACTL6Aactin-like 6A3q26.33AF041474 
    2290FOXG1forkhead box G114q13X74142 
    2958GTF2A2general transcription factor IIA, 2, 12kDa15q22.2U14193 
    3298HSF2heat shock transcription factor 26q22.31M65217 
    3475IFRD1interferon-related developmental regulator 17q22-q31Y10313 
    7050TGIF1TGFB-induced factor homeobox 118p11.3X89750 
    10151HNRNPA3P1heterogeneous nuclear ribonucleoprotein A3 pseudogene 110q11.21S63912 
    3183HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)14q11.2M16342 
    1933EEF1B2eukaryotic translation elongation factor 1 beta 22q33-q34X60489 
    8467SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 54q31.1-q31.2AB010882 
    8725C19orf2chromosome 19 open reading frame 219q12AB006572 
    8405SPOPspeckle-type POZ protein17q21.33AJ000644 
    8099CDK2AP1CDK2-associated protein 112q24.31AF006484 
    730092LOC730092-16p12.1AF001549 
    9203ZMYM3zinc finger, MYM-type 3Xq13.1X95808 
    4781NFIBnuclear factor I/B9p24.1U70862 
    7644ZNF91zinc finger protein 9119p13.1-p12L11672 
    4862NPAS2neuronal PAS domain protein 22q11.2U77970 
    3110MNX1motor neuron and pancreas homeobox 17q36U07664 
    27287VENTXVENT homeobox homolog (Xenopus laevis)10q26.3AF068006 
    22936ELL2elongation factor, RNA polymerase II, 25q15U88629 
    6433SFRS8splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila)12q24.33U08377 
    374868ATP9BATPase, class II, type 9B18q23AJ006268 
    3156HMGCR3-hydroxy-3-methylglutaryl-Coenzyme A reductase5q13.3-q14M11058 
    460ASTN1astrotactin 11q25.2AB006627 
    1806DPYDdihydropyrimidine dehydrogenase1p22U20938 
    10309CCNOcyclin O5p15.2-p13.1X52486 
    4836NMT1N-myristoyltransferase 117q21.31AF043324 
    2593GAMTguanidinoacetate N-methyltransferase19p13.3AC005329 
    5264PHYHphytanoyl-CoA 2-hydroxylase10pter-p11.2AF023462 
    2632GBE1glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)3p12.3L07956 
    2923PDIA3protein disulfide isomerase family A, member 315q15Z49835 
    23163GGA3golgi associated, gamma adaptin ear containing, ARF binding protein 317q25.1D63876 
    6414SEPP1selenoprotein P, plasma, 15q31Z11793 
    821CANXcalnexin5q35L10284 
    3920LAMP2lysosomal-associated membrane protein 2Xq24U36336 
    6902TBCAtubulin folding cofactor A5q14.1AF038952 
    4430MYO1Bmyosin IB2q12-q34AJ001381 
    9276COPB2coatomer protein complex, subunit beta 2 (beta prime)3q23X70476 
    1605DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)3p21L19711 
    5346PLINperilipin15q26AB005293 
    10947AP3M2adaptor-related protein complex 3, mu 2 subunit8p11.2D38293 
    4515MTCP1mature T-cell proliferation 1Xq28Z24459 
    11145HRASLS3HRAS-like suppressor 311q12.3-q13.1X92814 
    23169SLC35D1solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D11p32-p31D87449 
    11235PDCD10programmed cell death 103q26.1AF022385 
        L049851 
    10105PPIFpeptidylprolyl isomerase F (cyclophilin F)10q22-q23M80254 
    221823PRPS1L1phosphoribosyl pyrophosphate synthetase 1-like 17p21.1M57423 
    1549CYP2A7cytochrome P450, family 2, subfamily A, polypeptide 719q13.2M33317 
    10965ACOT2acyl-CoA thioesterase 214q24.3L40401 
    4647MYO7Amyosin VIIA11q13.5U39226 
    1822ATN1atrophin 112p13.31D31840 
    9121SLC16A5solute carrier family 16, member 5 (monocarboxylic acid transporter 6)17q25.1U59299 
    9311ACCN3amiloride-sensitive cation channel 37q35AB010575 
    23443SLC35A3solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A31p21AB021981 
    2760GM2AGM2 ganglioside activator5q31.3-q33.1AA224768 
    118ADD1adducin 1 (alpha)4p16.3L07261 
    3107HLA-Cmajor histocompatibility complex, class I, C6p21.3X96754 
    4583MUC2mucin 2, oligomeric mucus/gel-forming11p15.5M57417 
    10616RBCK1RanBP-type and C3HC4-type zinc finger containing 120p13AA160708 
    65110UPF3AUPF3 regulator of nonsense transcripts homolog A (yeast)13q34N36842 
    57498KIDINS220-2p24W27233 
    55786ZNF415zinc finger protein 41519q13.41AF038179 
        AF052141 
    51029FAM152Afamily with sequence similarity 152, member A1q44AL049397 
    129642MBOAT2membrane bound O-acyltransferase domain containing 22p25.1AF052107 
    23136EPB41L3erythrocyte membrane protein band 4.1-like 318p11.32AB023204 
    9716AQRaquarius homolog (mouse)15q14AB011132 
    9890LPPR4-1p21.2AB007924 
    9706ULK2unc-51-like kinase 2 (C. elegans)17p11.2AB014523 
    92482LOC92482-10q25.2AI692348 
    84869CBR4carbonyl reductase 44q32.3AL049442 
    9816KIAA0133KIAA01331q42.13D50923 
        AW026535 
    23394ADNPactivity-dependent neuroprotector homeobox20q13.13AB018327 
    22828RBM16RNA binding motif protein 166q25.1-q25.3AB029039 
    23244PDS5APDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)4p14AB014548 
    10907TXNL4Athioredoxin-like 4A18q23AF023612 
    10447FAM3Cfamily with sequence similarity 3, member C7q31D87120 
    9802DAZAP2DAZ associated protein 212q12D31767 
    57158JPH2junctophilin 220q13.12AL035447 
    10972TMED10transmembrane emp24-like trafficking protein 10 (yeast)14q24.3L40397 
    51669TMEM66transmembrane protein 668p12W26659 
    10724MGEA5meningioma expressed antigen 5 (hyaluronidase)10q24.1-q24.3AB014579 
    5962RDXradixin11q23N92548 
    22891ZNF365zinc finger protein 36510q21.2AB020651 
    10614HEXIM1hexamethylene bis-acetamide inducible 117q21.31AB021179 
    30836DNTTIP2deoxynucleotidyltransferase, terminal, interacting protein 21p22.1U15552 
    10542HBXIPhepatitis B virus x interacting protein1p13.3AF029890 
    26009ZZZ3zinc finger, ZZ-type containing 31p31.1AL080063 
    9884LRRC37Aleucine rich repeat containing 37A17q21.31H16917 
    91977MYOZ3myozenin 35q33.1AF052497 
        AF038194 
    3842TNPO1transportin 15q13.2AL049378 
    534ATP6V1G2ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G26p21.3W26326 
    9721GPRIN2G protein regulated inducer of neurite outgrowth 210q11.22AB011086 
    26045LRRTM2leucine rich repeat transmembrane neuronal 25q31.2AB007876 
    57240KIAA0484--AB007953 
    747DAGLAdiacylglycerol lipase, alpha11q12.2AB014559 
    711C3orf51chromosome 3 open reading frame 51-U88965 
    81611ANP32Eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E1q21.2W25866 
    9699RIMS2regulating synaptic membrane exocytosis 28q22.3AB018294 
    26135SERBP1SERPINE1 mRNA binding protein 11p31AL080119 
        S80864 
    4609MYCv-myc myelocytomatosis viral oncogene homolog (avian)8q24.21M13929