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Gene Information
Gene ID:2632
Symbol:GBE1
Full Name:glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)
Alias:GBE
Organism:Homo sapiens (Human)
Chromosome:3
Genetic Location:3p12.3
Physical Location:81621540-81893639 on NC_000003.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L07956
Fold Change:0.7
P Value:0.002
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000158.3NP_000149.3NC_000003.10 range: 81621540..81893639, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (8613547)
GO:00038441,4-alpha-glucan branching enzyme activityMolecular FunctionEXP (8613547)
GO:00038441,4-alpha-glucan branching enzyme activityMolecular FunctionTAS (8613547)
GO:0004553hydrolase activity, hydrolyzing O-glycosyl compoundsMolecular FunctionIEA
GO:0016757transferase activity, transferring glycosyl groupsMolecular FunctionIEA
GO:0043169cation bindingMolecular FunctionIEA
GO:0005975carbohydrate metabolic processBiological ProcessIEA
GO:0005978glycogen biosynthetic processBiological ProcessIEA
GO:0006091generation of precursor metabolites and energyBiological ProcessTAS (8613547)
Other Database Cross Links
NCBI Entrez Gene:2632
HGNC:4180
Ensembl:
MIM:607839
HPRD:01985
HuGE Navigator:2632
dbSNP:GBE1
GeneCard:GBE1
AceView:GBE1