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Gene Information
Gene ID:8851
Full Name:cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Organism:Homo sapiens (Human)
Genetic Location:17q11.2
Physical Location:27838217-27842383 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AI003191
Fold Change:1.4, 1.4
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Information
Original ID1:X80343
Fold Change:2.52
P Value:0.0012
Dataset Information
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Information
Original ID1:CDK5R1
Dataset Information
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Linkage Dataset
MarkerLODP valueLocation (bp)
D17S798  28313925
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003885.2NP_003876.1NC_000017.9 range: 27838217..27842383
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030426growth coneCellular ComponentISS
GO:0030424axonCellular ComponentISS
GO:0016533cyclin-dependent protein kinase 5 activator complexCellular ComponentIEA
GO:0016020membraneCellular ComponentISS
GO:0031594neuromuscular junctionCellular ComponentISS
GO:0043025cell somaCellular ComponentISS
GO:0043197dendritic spineCellular ComponentISS
GO:0043292contractile fiberCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0005634nucleusCellular ComponentISS
GO:0043539protein serine/threonine kinase activator activityMolecular FunctionISS
GO:0045296cadherin bindingMolecular FunctionISS
GO:0016534cyclin-dependent protein kinase 5 activator activityMolecular FunctionIEA
GO:0004672protein kinase activityMolecular FunctionTAS (7592934)
GO:0005509calcium ion bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (10721722|12223541)
GO:0005515protein bindingMolecular FunctionISS
GO:0031175neurite developmentBiological ProcessISS
GO:0035235ionotropic glutamate receptor signaling pathwayBiological ProcessISS
GO:0043525positive regulation of neuron apoptosisBiological ProcessISS
GO:0000079regulation of cyclin-dependent protein kinase activityBiological ProcessTAS (7592934)
GO:0009790embryonic developmentBiological ProcessISS
GO:0001764neuron migrationBiological ProcessISS
GO:0007158neuron adhesionBiological ProcessISS
GO:0007213acetylcholine receptor signaling, muscarinic pathwayBiological ProcessISS
GO:0007411axon guidanceBiological ProcessISS
GO:0007413axonal fasciculationBiological ProcessISS
GO:0007420brain developmentBiological ProcessISS
GO:0007420brain developmentBiological ProcessNAS (10915792)
GO:0008283cell proliferationBiological ProcessTAS (8090221)
GO:0045664regulation of neuron differentiationBiological ProcessNAS (10721722)
Other Database Cross Links
NCBI Entrez Gene:8851
HuGE Navigator:8851