ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

8851

Symbol:

CDK5R1

Full Name:

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Alias:

CDK5P35|CDK5R|MGC33831|NCK5A|p23|p25|p35|p35nck5a

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q11.2

Physical Location:

27838217-27842383 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI003191
Fold Change:		1.4, 1.4
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:		X80343
Fold Change:		2.52
P Value:		0.0012

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Information

Original ID1:

CDK5R1

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S798

28313925

Region:		26313925-30313925
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003885.2	NP_003876.1	NC_000017.9 range: 27838217..27842383

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030426	growth cone	Cellular Component	ISS
GO:0030424	axon	Cellular Component	ISS
GO:0016533	cyclin-dependent protein kinase 5 activator complex	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	ISS
GO:0031594	neuromuscular junction	Cellular Component	ISS
GO:0043025	cell soma	Cellular Component	ISS
GO:0043197	dendritic spine	Cellular Component	ISS
GO:0043292	contractile fiber	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	ISS
GO:0043539	protein serine/threonine kinase activator activity	Molecular Function	ISS
GO:0045296	cadherin binding	Molecular Function	ISS
GO:0016534	cyclin-dependent protein kinase 5 activator activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	TAS (7592934)
GO:0005509	calcium ion binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI (10721722\|12223541)
GO:0005515	protein binding	Molecular Function	ISS
GO:0031175	neurite development	Biological Process	ISS
GO:0035235	ionotropic glutamate receptor signaling pathway	Biological Process	ISS
GO:0043525	positive regulation of neuron apoptosis	Biological Process	ISS
GO:0000079	regulation of cyclin-dependent protein kinase activity	Biological Process	TAS (7592934)
GO:0009790	embryonic development	Biological Process	ISS
GO:0001764	neuron migration	Biological Process	ISS
GO:0007158	neuron adhesion	Biological Process	ISS
GO:0007213	acetylcholine receptor signaling, muscarinic pathway	Biological Process	ISS
GO:0007411	axon guidance	Biological Process	ISS
GO:0007413	axonal fasciculation	Biological Process	ISS
GO:0007420	brain development	Biological Process	ISS
GO:0007420	brain development	Biological Process	NAS (10915792)
GO:0008283	cell proliferation	Biological Process	TAS (8090221)
GO:0045664	regulation of neuron differentiation	Biological Process	NAS (10721722)