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Gene Information
Gene ID:6792
Symbol:CDKL5
Full Name:cyclin-dependent kinase-like 5
Alias:ISSX|STK9
Organism:Homo sapiens (Human)
Chromosome:X
Genetic Location:Xp22
Physical Location:18353645-18581669 on NC_000023.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X89059
Fold Change:1.9
P Value:0.033
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001037343.1NP_001032420.1NC_000023.9 range: 18353645..18581669
NM_003159.2NP_003150.1NC_000023.9 range: 18353645..18581669
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (16935860)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0004693cyclin-dependent protein kinase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIDA (16935860)
GO:0016740transferase activityMolecular FunctionIEA
GO:0046777protein amino acid autophosphorylationBiological ProcessIDA (16935860)
Other Database Cross Links
NCBI Entrez Gene:6792
HGNC:11411
Ensembl:ENSG00000008086
MIM:300203
HPRD:02190
HuGE Navigator:6792
dbSNP:CDKL5
GeneCard:CDKL5
AceView:CDKL5