ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

DHX9

Full Name:

DEAH (Asp-Glu-Ala-His) box polypeptide 9

Alias:

DDX9|LKP|NDHII|RHA

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q25

Physical Location:

181075073-181123506 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 13211 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001357.3	NP_001348.2	NC_000001.9 range: 181075073..181123506

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	TAS (8690889)
GO:0005634	nucleus	Cellular Component	TAS (9111062)
GO:0005622	intracellular	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10924507\|15084609\|15355351\|17353931)
GO:0004004	ATP-dependent RNA helicase activity	Molecular Function	TAS (9111062)
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	TAS (9111062)
GO:0003725	double-stranded RNA binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0000398	nuclear mRNA splicing, via spliceosome	Biological Process	EXP (12226669)