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Gene Information
Gene ID:7881
Symbol:KCNAB1
Full Name:potassium voltage-gated channel, shaker-related subfamily, beta member 1
Alias:AKR6A3|KCNA1B|KV-BETA-1|Kvb1.3|hKvBeta3|hKvb3
Organism:Homo sapiens (Human)
Chromosome:3
Genetic Location:3q26.1
Physical Location:157321030-157739620 on NC_000003.10
Gene Type:protein-coding
Orthologs:This gene has Rat: 29737 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L39833
Fold Change:0.8
P Value:0.011
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003471.3NP_003462.2NC_000003.10 range: 157321030..157739620
NM_172159.3NP_751891.1NC_000003.10 range: 157321030..157739620
NM_172160.2NP_751892.1NC_000003.10 range: 157321030..157739620
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0015459potassium channel regulator activityMolecular FunctionTAS (7499366)
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:0005249voltage-gated potassium channel activityMolecular FunctionIEA
GO:0006813potassium ion transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006813potassium ion transportBiological ProcessTAS (7499366)
Other Database Cross Links
NCBI Entrez Gene:7881
HGNC:6228
Ensembl:ENSG00000169282
MIM:601141
HPRD:03089
HuGE Navigator:7881
dbSNP:KCNAB1
GeneCard:KCNAB1
AceView:KCNAB1