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Gene Information
Gene ID:29737
Symbol:Kcnab1
Full Name:potassium voltage-gated channel, shaker-related subfamily, beta member 1
Alias:KvBeta3|MGC105463
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q31
Physical Location:154837840-155145884 on NC_005101.2
Gene Type:protein-coding
Human Ortholog:GeneID: 7881    Symbol (Name): KCNAB1 (potassium voltage-gated channel, shaker-related subfamily, beta member 1)
Ortholog Status:The human GeneID 7881 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Kcnab1
Fold Change:1.26
P Value:0.005
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017303.2NP_058999.1NC_005101.2 range: 154837840..155145884
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005249voltage-gated potassium channel activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006813potassium ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:29737
RGD:61827
Ensembl:ENSRNOG00000010422
dbSNP:Kcnab1