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Gene Information
Gene ID:324
Symbol:APC
Full Name:adenomatous polyposis coli
Alias:BTPS2|DP2|DP2.5|DP3|GS
Organism:Homo sapiens (Human)
Chromosome:5
Genetic Location:5q21-q22
Physical Location:112101482-112209834 on NC_000005.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M74088
Fold Change:4.8
P Value:0.01187
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Information
Original ID1:APC
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000038.4NP_000029.2NC_000005.8 range: 112101482..112209834
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000776kinetochoreCellular ComponentIDA (11283619)
GO:0016328lateral plasma membraneCellular ComponentIDA (12072559)
GO:0030877beta-catenin destruction complexCellular ComponentIDA (9601641|16188939)
GO:0005829cytosolCellular ComponentEXP (11955436|12000790|12820959|15327769|16753179)
GO:0005813centrosomeCellular ComponentIDA (11283619)
GO:0005737cytoplasmCellular ComponentIDA (11035805|12955080)
GO:0005634nucleusCellular ComponentIDA (11035805|12955080)
GO:0019901protein kinase bindingMolecular FunctionIDA (11283619)
GO:0008605protein kinase CK2 regulator activityMolecular FunctionIDA (11972058)
GO:0008017microtubule bindingMolecular FunctionIDA (11166179|16188939)
GO:0008013beta-catenin bindingMolecular FunctionNAS (8259518)
GO:0008013beta-catenin bindingMolecular FunctionIPI (11533658)
GO:0060070Wnt receptor signaling pathway through beta-cateninBiological ProcessIC (9601641)
GO:0051988regulation of attachment of spindle microtubules to kinetochoreBiological ProcessNAS (11283619)
GO:0045736negative regulation of cyclin-dependent protein kinase activityBiological ProcessIDA (8521819)
GO:0006461protein complex assemblyBiological ProcessIDA (16188939)
GO:0006974response to DNA damage stimulusBiological ProcessIDA (14728717)
GO:0007026negative regulation of microtubule depolymerizationBiological ProcessIDA (11166179)
GO:0007050cell cycle arrestBiological ProcessIDA (8521819)
GO:0008285negative regulation of cell proliferationBiological ProcessIDA (8521819)
GO:0007155cell adhesionBiological ProcessNAS (8259518)
GO:0060070Wnt receptor signaling pathway through beta-cateninBiological ProcessNAS (11035805)
Other Database Cross Links
NCBI Entrez Gene:324
HGNC:583
Ensembl:ENSG00000134982
MIM:611731
HPRD:01439
HuGE Navigator:324
dbSNP:APC
GeneCard:APC
AceView:APC