ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HEXIM1

Full Name:

hexamethylene bis-acetamide inducible 1

Alias:

CLP1|EDG1|FLJ13562|HIS1|MAQ1

Organism:

Homo sapiens (Human)

Chromosome:

17

Genetic Location:

17q21.31

Physical Location:

40580466-40585250 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AB021179
Fold Change:		0.59
P Value:		0.005

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006460.2	NP_006451.1	NC_000017.9 range: 40580466..40585250

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12581153)
GO:0005737	cytoplasm	Cellular Component	IDA (12581153)
GO:0004861	cyclin-dependent protein kinase inhibitor activity	Molecular Function	IDA (14580347)
GO:0005515	protein binding	Molecular Function	IPI (14580347\|15713661\|15941832)
GO:0017069	snRNA binding	Molecular Function	IDA (14580347)
GO:0016564	transcription repressor activity	Molecular Function	IDA (14580347)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (14580347)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	Biological Process	IDA (14580347)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000186834

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: