ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PTPRE

Full Name:

protein tyrosine phosphatase, receptor type, E

Alias:

DKFZp313F1310|HPTPE|PTPE|R-PTP-EPSILON

Organism:

Homo sapiens (Human)

Chromosome:

10

Genetic Location:

10q26

Physical Location:

129595314-129774154 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X54134
Fold Change:		1.48
P Value:		0.007

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006504.3	NP_006495.1	NC_000010.9 range: 129595314..129774154
NM_130435.2	NP_569119.1	NC_000010.9 range: 129595314..129774154

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005625	soluble fraction	Cellular Component	NR
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	NR
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Molecular Function	TAS (2170109)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	TAS (2170109)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000132334

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: