ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TRPC1

Full Name:

transient receptor potential cation channel, subfamily C, member 1

Alias:

HTRP-1|MGC133334|MGC133335|TRP1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3q22-q24

Physical Location:

143925955-144009419 on NC_000003.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 22063 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003304.4	NP_003295.1	NC_000003.10 range: 143925955..144009419

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	NAS (8663995)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (7568191)
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15757897)
GO:0015279	store-operated calcium channel activity	Molecular Function	TAS (8663995)
GO:0006811	ion transport	Biological Process	IEA
GO:0006816	calcium ion transport	Biological Process	TAS (8646775)