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Gene Information
Gene ID:7220
Symbol:TRPC1
Full Name:transient receptor potential cation channel, subfamily C, member 1
Alias:HTRP-1|MGC133334|MGC133335|TRP1
Organism:Homo sapiens (Human)
Chromosome:3
Genetic Location:3q22-q24
Physical Location:143925955-144009419 on NC_000003.10
Gene Type:protein-coding
Orthologs:This gene has Mouse: 22063 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X89066
Fold Change:0.69
P Value:0.0058
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003304.4NP_003295.1NC_000003.10 range: 143925955..144009419
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentNAS (8663995)
GO:0005887integral to plasma membraneCellular ComponentTAS (7568191)
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (15757897)
GO:0015279store-operated calcium channel activityMolecular FunctionTAS (8663995)
GO:0006811ion transportBiological ProcessIEA
GO:0006816calcium ion transportBiological ProcessTAS (8646775)
Other Database Cross Links
NCBI Entrez Gene:7220
HGNC:12333
Ensembl:ENSG00000144935
MIM:602343
HPRD:11894
HuGE Navigator:7220
dbSNP:TRPC1
GeneCard:TRPC1
AceView:TRPC1