ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC35D1

Full Name:

solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

Alias:

KIAA0260|MGC138236|UGTREL7

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p32-p31

Physical Location:

67242438-67292315 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_015139.1	NP_055954.1	NC_000001.9 range: 67242438..67292315, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0030176	integral to endoplasmic reticulum membrane	Cellular Component	NAS
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005351	sugar:hydrogen symporter activity	Molecular Function	IEA
GO:0005463	UDP-N-acetylgalactosamine transmembrane transporter activity	Molecular Function	NAS
GO:0015789	UDP-N-acetylgalactosamine transport	Biological Process	NAS
GO:0008643	carbohydrate transport	Biological Process	IEA
GO:0030206	chondroitin sulfate biosynthetic process	Biological Process	NAS