ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PPP3CB

Full Name:

protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform

Alias:

CALNA2|CALNB

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10q21-q22

Physical Location:

74866617-74925757 on NC_000010.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M29551
Fold Change:		2.4, 2.5
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021132.1	NP_066955.1	NC_000010.9 range: 74866617..74925757, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005955	calcineurin complex	Cellular Component	IDA (8524402)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	IEA
GO:0005516	calmodulin binding	Molecular Function	NAS (8524402)
GO:0005509	calcium ion binding	Molecular Function	IDA (8524402)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0004722	protein serine/threonine phosphatase activity	Molecular Function	NAS (8392375)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006351	transcription, DNA-dependent	Biological Process	NR
GO:0006470	protein amino acid dephosphorylation	Biological Process	NR
GO:0007165	signal transduction	Biological Process	NAS (8978785)