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Gene Information
Gene ID:5532
Symbol:PPP3CB
Full Name:protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
Alias:CALNA2|CALNB
Organism:Homo sapiens (Human)
Chromosome:10
Genetic Location:10q21-q22
Physical Location:74866617-74925757 on NC_000010.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M29551
Fold Change:2.4, 2.5
Note:Differential expression on the oligonucleotide array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Information
Original ID1:M29550
Fold Change:0.77
P Value:0.001
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_021132.1NP_066955.1NC_000010.9 range: 74866617..74925757, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005955calcineurin complexCellular ComponentIDA (8524402)
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0004721phosphoprotein phosphatase activityMolecular FunctionIEA
GO:0005516calmodulin bindingMolecular FunctionNAS (8524402)
GO:0005509calcium ion bindingMolecular FunctionIDA (8524402)
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0004722protein serine/threonine phosphatase activityMolecular FunctionNAS (8392375)
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0006351transcription, DNA-dependentBiological ProcessNR
GO:0006470protein amino acid dephosphorylationBiological ProcessNR
GO:0007165signal transductionBiological ProcessNAS (8978785)
Other Database Cross Links
NCBI Entrez Gene:5532
HGNC:9315
Ensembl:ENSG00000107758
MIM:114106
HPRD:00235
HuGE Navigator:5532
dbSNP:PPP3CB
GeneCard:PPP3CB
AceView:PPP3CB