ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PDIA3

Full Name:

protein disulfide isomerase family A, member 3

Alias:

ER60|ERp57|ERp60|ERp61|GRP57|GRP58|HsT17083|P58|PI-PLC

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

15q15

Physical Location:

41825881-41852095 on NC_000015.8

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14827 Rat: 29468 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Information

Original ID1:

PDIA3

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005313.4	NP_005304.3	NC_000015.8 range: 41825881..41852095

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	TAS (16130169)
GO:0005788	endoplasmic reticulum lumen	Cellular Component	IEA
GO:0042470	melanosome	Cellular Component	IEA
GO:0003756	protein disulfide isomerase activity	Molecular Function	TAS (8624847)
GO:0004197	cysteine-type endopeptidase activity	Molecular Function	TAS (9399589)
GO:0004629	phospholipase C activity	Molecular Function	TAS (3398923)
GO:0005515	protein binding	Molecular Function	IPI (16368681\|17055437)
GO:0016853	isomerase activity	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	TAS (3398923)
GO:0006621	protein retention in ER	Biological Process	TAS (9399589)
GO:0006606	protein import into nucleus	Biological Process	TAS (7487104)
GO:0045454	cell redox homeostasis	Biological Process	IEA