ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdia3

Full Name:

protein disulfide isomerase associated 3

Alias:

ER60|ERp57|Grp58

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q35

Physical Location:

108216413-108240137 on NC_005102.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2923 Symbol (Name): PDIA3 (protein disulfide isomerase family A, member 3)

Ortholog Status:

The human GeneID 2923 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.11527
Fold Change:		1.19
P Value:		0.00286
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017319.1	NP_059015.1	NC_005102.2 range: 108216413..108240137

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005788	endoplasmic reticulum lumen	Cellular Component	IEA
GO:0042470	melanosome	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	ISS
GO:0016853	isomerase activity	Molecular Function	IEA
GO:0003756	protein disulfide isomerase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0043065	positive regulation of apoptosis	Biological Process	IEA
GO:0043065	positive regulation of apoptosis	Biological Process	ISS
GO:0045454	cell redox homeostasis	Biological Process	IEA