ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdia3

Full Name:

protein disulfide isomerase associated 3

Alias:

58kDa|ERp57|ERp60|ERp61|Erp|Grp58|PDI|PDI-Q2|PI-PLC|PLC[a]|Plca

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 E5|2 69.0 cM

Physical Location:

121239637-121264422 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2923 Symbol (Name): PDIA3 (protein disulfide isomerase family A, member 3)

Ortholog Status:

The human GeneID 2923 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Grp58
Original ID2:		M73329

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007952.2	NP_031978.2	NC_000068.6 range: 121239637..121264422

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005783	endoplasmic reticulum	Cellular Component	IDA (9493907)
GO:0003756	protein disulfide isomerase activity	Molecular Function	IEA
GO:0016853	isomerase activity	Molecular Function	IEA
GO:0043065	positive regulation of apoptosis	Biological Process	IMP (15858817)
GO:0045454	cell redox homeostasis	Biological Process	IEA