ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RHEB

Full Name:

Ras homolog enriched in brain

Alias:

MGC111559|RHEB2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7q36

Physical Location:

150794030-150847942 on NC_000007.12, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 19744 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005614.3	NP_005605.1	NC_000007.12 range: 150794030..150847942, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (15755954\|15809305\|15951850)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	TAS (8206940)
GO:0005525	GTP binding	Molecular Function	TAS (8543055)
GO:0007165	signal transduction	Biological Process	TAS (8661031)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA