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Gene Information
Gene ID:9770
Symbol:RASSF2
Full Name:Ras association (RalGDS/AF-6) domain family member 2
Alias:DKFZp781O1747|KIAA0168|RASFADIN
Organism:Homo sapiens (Human)
Chromosome:20
Genetic Location:20pter-p12.1
Physical Location:4708668-4752290 on NC_000020.9, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 215653 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:D79990
Fold Change:0.81
P Value:0.0079
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Information
Original ID1:RASSF2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_014737.2NP_055552.1NC_000020.9 range: 4708668..4752290, complement
NM_170774.1NP_739580.1NC_000020.9 range: 4708668..4752290, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIPI (12732644)
GO:0007165signal transductionBiological ProcessIEA
GO:0045786negative regulation of cell cycleBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:9770
HGNC:9883
Ensembl:ENSG00000101265
MIM:609492
HPRD:15218
HuGE Navigator:9770
dbSNP:RASSF2
GeneCard:RASSF2
AceView:RASSF2