ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ATRX

Full Name:

alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)

Alias:

ATR2|MGC2094|MRXHF1|RAD54|RAD54L|SFM1|SHS|XH2|XNP|ZNF-HX

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

Xq13.1-q21.1

Physical Location:

76647011-76928374 on NC_000023.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 246284 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005720	nuclear heterochromatin	Cellular Component	TAS (10570185)
GO:0005634	nucleus	Cellular Component	TAS (7874112)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12953102)
GO:0003700	transcription factor activity	Molecular Function	NR
GO:0003678	DNA helicase activity	Molecular Function	TAS (7697714)
GO:0006306	DNA methylation	Biological Process	TAS (10742099)
GO:0006310	DNA recombination	Biological Process	TAS (7697714)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	TAS (7697714)
GO:0007605	sensory perception of sound	Biological Process	IEA
GO:0006281	DNA repair	Biological Process	TAS (7697714)