Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:246284
Full Name:alpha thalassemia/mental retardation syndrome X-linked homolog (human)
Organism:Rattus norvegicus (Rat)
Genetic Location:Xq31
Physical Location:93905568-94050359 on NC_005120.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 546    Symbol (Name): ATRX (alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae))
Ortholog Status:The human GeneID 546 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Atrx
Fold Change:-1.22
P Value:0.006
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Atrx
Fold Change:-1.29
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:Atrx
Fold Change:-1.26
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_217570.4XP_217570.4NC_005120.2 range: 93905568..94050359, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000228nuclear chromosomeCellular ComponentISS
GO:0000792heterochromatinCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0005575cellular_componentCellular ComponentND
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (8667030)
GO:0004386helicase activityMolecular FunctionIEA
GO:0003682chromatin bindingMolecular FunctionISS
GO:0003677DNA bindingMolecular FunctionIEA
GO:0006281DNA repairBiological ProcessIEA
GO:0008150biological_processBiological ProcessND
GO:0030900forebrain developmentBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:246284