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Gene Information
Gene ID:10456
Symbol:HAX1
Full Name:HCLS1 associated protein X-1
Alias:FLJ17042|FLJ18492|FLJ93803|HCLSBP1|HS1BP1|SCN3
Organism:Homo sapiens (Human)
Chromosome:1
Genetic Location:1q21.3
Physical Location:152511662-152514974 on NC_000001.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U68566
Fold Change:0.88
P Value:0.046
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001018837.1NP_001018238.1NC_000001.9 range: 152511662..152514974
NM_006118.3NP_006109.2NC_000001.9 range: 152511662..152514974
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005625soluble fractionCellular ComponentTAS (9058808)
GO:0005634nucleusCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentTAS (9058808)
GO:0005783endoplasmic reticulumCellular ComponentTAS (9058808)
GO:0015629actin cytoskeletonCellular ComponentNAS (10760273)
GO:0016020membraneCellular ComponentIEA
GO:0031965nuclear membraneCellular ComponentIEA
GO:0019966interleukin-1 bindingMolecular FunctionIDA (11554782)
GO:0047485protein N-terminus bindingMolecular FunctionIDA (11554782)
Other Database Cross Links
NCBI Entrez Gene:10456
HGNC:16915
Ensembl:ENSG00000143575
MIM:605998
HPRD:12075
HuGE Navigator:10456
dbSNP:HAX1
GeneCard:HAX1
AceView:HAX1