ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RNF139

Full Name:

ring finger protein 139

Alias:

HRCA1|MGC31961|RCA1|TRC8

Organism:

Homo sapiens (Human)

Chromosome:

8

Genetic Location:

8q24

Physical Location:

125556188-125570039 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF064801
Fold Change:		0.81
P Value:		0.031

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007218.3	NP_009149.2	NC_000008.9 range: 125556188..125570039

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IDA (12032852)
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	TAS (12032852)
GO:0016020	membrane	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	TAS (9689122)
GO:0016874	ligase activity	Molecular Function	TAS (10500182)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12032852)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0031396	regulation of protein ubiquitination	Biological Process	IDA (10500182)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000170881

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: