| Gene Information |
| Gene ID: | | 3475 |
| Symbol: | | IFRD1 |
| Full Name: | | interferon-related developmental regulator 1 |
| Alias: | | PC4|TIS7 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 7 |
| Genetic Location: | | 7q22-q31 |
| Physical Location: | | 111850461-111903482 on NC_000007.12 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Y10313 | | Fold Change: | | 0.69 | | P Value: | | 0.0033 |
| | Dataset Information | | Name: | | 12774316 | | Method: | | Microarray | | Tissue: | | Temporal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed | | Summary: | | To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly. |
| | Gene Information | | Original ID1: | | Hs.7879 | | Note: | | "Class II, down-regulated gene" |
| | Dataset Information | | Name: | | 16292326 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed | | Summary: | | In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005488 | binding | Molecular Function | IEA | |
| GO:0007275 | multicellular organismal development | Biological Process | IEA | |
| GO:0007518 | myoblast cell fate determination | Biological Process | TAS (7756174) | |
| GO:0030154 | cell differentiation | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 3475 |
| HGNC: | | 5456 |
| Ensembl: | | ENSG00000006652 |
| MIM: | | 603502 |
| HPRD: | | 04612 |
| HuGE Navigator: | | 3475 |
| dbSNP: | | IFRD1 |
| GeneCard: | | IFRD1 |
| AceView: | | IFRD1 |
